Improving women’s reproductive health by studying the endometrium
The endometrium is the mucosal lining of the uterus that is composed of stromal and epithelial cells and undergoes 400-500 cycles of proliferation, differentiation and menstrual breakdown throughout a woman’s lifespan. The endometrial tissue’s capacity for self-renewal is attributed to the presence of stem cells. Using mouse models, innovative primary-derived 3D-organoids and 2D-stromal cells from human endometrial tissues, our goal is to unravel the signals which prepare the endometrium for pregnancy by controlling epithelial cell remodeling, stromal cell differentiation, and regeneration. This knowledge holds potential to address disease that affect the endometrium, such as endometriosis, endometrial cancer, menstrual disorders and infertility.
“Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis”
Nature Communications volume 12, Article number: 3386 (2021)
“Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers”
Oncogene volume 40, pages 2081–2095 (2021)
“Activin-like kinase 5 (ALK5) inactivation in the mouse uterus results in metastatic endometrial carcinoma”
PNAS February 26, 2019 116 (9) 3883-3892
Complete list of publications can be found here:
Kersten is an undergraduate student at Spelman University. Kersten joined the group as part of the summer SMART program at BCM and worked on projects related endometrial cancer drug discovery.